A general solid phase method for the preparation of diverse azapeptide probes directed against cysteine proteases.
نویسندگان
چکیده
[chemical reaction: see text]. A solid phase approach is presented for the synthesis of azapeptide inhibitors and activity based probes (ABPs) for cysteine proteases. This synthetic method allows the incorporation of diverse reactive warheads linked to different peptide recognition elements. Application of this method to the synthesis of a series of caspase probes is described.
منابع مشابه
Novel aza peptide inhibitors and active-site probes of papain-family cysteine proteases.
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عنوان ژورنال:
- Organic letters
دوره 7 25 شماره
صفحات -
تاریخ انتشار 2005